Pain

Using a Pain Diary

A pain diary to record chronic pain patterns and triggers can be useful to improve control of pain management.

Comparing Nociceptive and Neuropathic Pain

Antidepressants in Pain Management

Chronic Pain: The 20 Most Painful Conditions

Pain in the Lower Right Abdomen: When to be Concerned

Latest Pain News and Research

$Six week casting proves as effective as surgery for unstable ankle fractures$

Six week casting proves as effective as surgery for unstable ankle fractures

Wearing a cast for six weeks appears to be no less effective than surgery for healing unstable ankle fractures and carries fewer treatment related harms, finds a clinical trial from Finland published by The BMJ today.

14 Jan 2026

Bradycardia emerges as key clinical sign of xylazine-opioid overdose

Researchers have identified bradycardia-an abnormally low heart rate–as a symptom of xylazine-opioid overdose.

14 Jan 2026

HIF1 protein identified as key driver of tendon pain

Overuse of our tendons can cause painful medical conditions for which only limited treatment options exist. Researchers have now deciphered an important molecular mechanism that triggers these problems.

14 Jan 2026

Disease-responsive nanoparticles enable ghrelin mRNA therapy in osteoarthritis

Nitin Joshi, PhD, and Jingjing Gao, PhD, of the Department of Anesthesiology at Mass General Brigham, are the co-senior authors of a paper published in Nature Nanotechnology, "A disease-severity-responsive nanoparticle enables potent ghrelin mRNA therapy in osteoarthritis." Mahima Dewani, PhD, is the lead author of this study.

14 Jan 2026

RAS-MAPK inhibition halts spinal deformity in neurofibromatosis type 1 mouse model

Spinal deformities such as scoliosis and kyphosis are among the most serious complications of neurofibromatosis type 1 (NF1), a genetic disorder that affects about one in 3,000 people.

14 Jan 2026

Vaccines are helping older people more than we knew

Let's be clear: The primary reason to be vaccinated against shingles is that two shots provide at least 90% protection against a painful, blistering disease that a third of Americans will suffer in their lifetimes, one that can cause lingering nerve pain and other nasty long-term consequences.

14 Jan 2026

More surgical patients on opioid use disorder treatment demand updated pain care

As more Americans receive treatment for opioid use disorder, that progress is increasingly showing up in the operating room, creating an urgent need to modernize how pain is managed during and after major surgery, according to a study in the February 2026 issue of Anesthesiology, the peer-reviewed medical journal of the American Society of Anesthesiologists (ASA).

13 Jan 2026

Short-term, calorie-restrictive diet improves Crohn’s disease symptoms

A Stanford Medicine-led study finds a short-term, calorie-restrictive diet significantly improved symptoms.

13 Jan 2026

New research identifies faulty TRPM3 ion channel in ME/CFS immune cells

A faulty ion channel function is a consistent biological feature of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), providing long-awaited validation for hundreds of thousands of Australians living with the debilitating illness.

13 Jan 2026

Blood test opens the doors to early diagnosis and prevention of Crohn's disease

Sinai Health researchers have shown a blood test that can predict Crohn's disease years before symptoms appear, opening the doors to early diagnosis and potentially prevention.

12 Jan 2026

Social, family and health factors contribute to bullying among adolescents

Bullying in the United States remains a serious public health issue with consequences that extend far beyond the school grounds.

12 Jan 2026

DNA analysis of colorectal polyps improves diagnosis and treatment

In about 5–10% of colorectal cancer patients, hereditary factors play a role, with higher percentages among younger patients.

12 Jan 2026

Long COVID symptom clusters that could reshape patient care

A systematic review of Long COVID identifies symptom clusters, highlighting fatigue and proposing a management framework for personalized treatment strategies.

12 Jan 2026

Chronic back pain predicts poor sleep in older men

Researchers investigate the prevalence of back pain and sleep issues in men 65 years of age and older.

12 Jan 2026

‘Abortion as homicide’ debate in South Carolina exposes GOP rift as states weigh new restrictions

When a trio of Republican state lawmakers introduced a bill last year that would subject women who obtain abortions to decades in prison, some reproductive rights advocates feared South Carolina might pass the "most extreme" abortion ban in the United States.

12 Jan 2026

$Neural pain pathways found to play crucial role in bone fracture healing$

Neural pain pathways found to play crucial role in bone fracture healing

When a house catches on fire, we assume that a smoke alarm inside will serve one purpose and one purpose only: warn the occupants of danger.

8 Jan 2026

IV iron dextran more cost-effective than oral iron for women with heavy menstrual bleeding and IDA

A single dose of intravenous (IV) iron dextran is the cost-effective treatment for women with heavy menstrual bleeding and iron deficiency anemia (IDA), according to new research published in Blood Advances.

8 Jan 2026

Stimulating immune cells could offer new treatment for nerve injury pain

Researchers at The University of Texas MD Anderson Cancer Center have discovered that targeting a specific immune process could help improve recovery after nerve injury and reduce chronic pain.

7 Jan 2026

Day case surgery linked to significant readmission and chronic pain risks

Two new studies published in Anaesthesia (the journal of the Association of Anaesthetists) analyzing pain and other factors connected with day surgery in the UK show that around 1 in 8 patients having day-case surgery end up not going home and instead are admitted to hospital for various complications.

7 Jan 2026

Pain-sensing neurons in the gut spark inflammatory immune responses

Pain sensing neurons in the gut kindle inflammatory immune responses that cause allergies and asthma, according to a new study by Weill Cornell Medicine.

7 Jan 2026