Metabolism News and Research

Latest Metabolism News and Research

PRMT5 inhibition induces ferroptosis and enhances immunotherapy efficacy in renal cell carcinoma

Ferroptosis, a regulated cell death mechanism, is emerging as a promising target for cancer therapy. The process is mediated by the activity of acyl-CoA synthetase family member 4 (ACSL4) protein.

22 Sep 2025

New quintuple agonist shows promise for treating obesity and type 2 diabetes

Much excitement has built in recent years on the new class of incretin drugs that include glucagon-like-peptide-1 inhibitor (single agonists such as semaglutide) and also dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonists (dual agonists such tirzepatide).

21 Sep 2025

Coffee protects the liver by blocking inflammation and scarring, review finds

A new review in Biochemical Pharmacology synthesizes decades of research showing consistent links between regular coffee consumption and reduced risk of liver disease, including cirrhosis and liver cancer. Coffee’s bioactive compounds act on antioxidant, anti-inflammatory, antifibrotic, and metabolic pathways to slow liver damage progression.

21 Sep 2025

Glucose-fructose mix found in sugary drinks fuels colorectal cancer metastasis

A new study from researchers at The University of Texas MD Anderson Cancer Center shows that the glucose-fructose mix found in sugary drinks directly fuels metastasis in preclinical models of advanced colorectal cancer.

19 Sep 2025

Metabolic activity found to control the tempo of embryo segmentation clock

Pregnant women rely on a balanced diet and supplements to deliver proper nutrients to their babies, to ensure they grow healthfully.

19 Sep 2025

Microplastics pose potential risks to bone health

The production and use of over 400 million tons of plastic each year has polluted beaches, rivers, and even the deepest parts of the ocean, reaching depths of up to 11,000 meters.

18 Sep 2025

Evening meals hold the key to morning glucose control in prediabetes

The way glucose is regulated at night plays a key role in fasting glucose levels the next morning, when blood sugar is expected to be at its lowest.

18 Sep 2025

Advancing drug discovery with AI, generative chemistry, and 3D molecular design

Discover how AI, generative chemistry, and 3D molecular design are revolutionizing drug discovery.

From Optibrium Ltd. 18 Sep 2025

Scientists unveil new obesity drug that reprograms fat and energy use

Details of a new drug that aims to treat the underlying causes of obesity are being presented at the annual meeting of the European Association for the Study of Diabetes (EASD) in Vienna, Austria (15-19 September).

18 Sep 2025

Holder vs Retort: How milk pasteurization shapes preterm infants’ gut health

Researchers at Vanderbilt University Medical Center found that pasteurization methods shape the gut microbiomes of preterm infants fed donor human milk. Holder pasteurization preserved microbial diversity and beneficial taxa better than Retort, producing microbiomes more similar to those from mothers’ own milk.

17 Sep 2025

New genetic test can help predict how people will respond to weight-loss medications

Mayo Clinic researchers have developed a genetic test that can help predict how people will respond to weight loss medications such as GLP-1s.

17 Sep 2025

Peroxisomes identified as alternative heat producers in brown fat

Researchers at Washington University School of Medicine in St. Louis have identified a novel way brown fat - an energy-burning form of fat - can rev the body's metabolic engine, consuming cellular fuel and producing heat in a way that improves metabolic health.

17 Sep 2025

High fat diet impairs memory formation through autophagy dysfunction

Modern lifestyles and dietary changes have significantly increased the consumption of high-fat foods, contributing to a steep rise in the prevalence of obesity, diabetes, and metabolic disorders.

17 Sep 2025

New AI model predicts surgical complications more accurately than current scores

A new artificial intelligence model found previously undetected signals in routine heart tests that strongly predict which patients will suffer potentially deadly complications after surgery.

17 Sep 2025

Researchers provide new insights into how exercise helps lose weight

Researchers at Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children's Hospital, Stanford University School of Medicine and collaborating institutions provide new insights into how exercise helps lose weight.

16 Sep 2025

Cleveland Clinic study shows lasting benefits of weight-loss surgery over GLP-1 medicines

A large Cleveland Clinic study has found that people with obesity and type 2 diabetes who undergo weight-loss surgery live longer and face fewer serious health problems compared with those treated with GLP-1 receptor agonist medicines alone.

16 Sep 2025

Foods taste sweeter or saltier than before for some people taking Ozempic, Wegovy or Mounjaro

New research being presented at the Annual Meeting of the European Association for the Study of Diabetes (EASD) in Vienna, Austria (15-19 September) shows that some individuals who are taking Ozempic, Wegovy or Mounjaro find that foods taste sweeter or saltier than before.

16 Sep 2025

Daily meal timing influences longevity risk in adults, study reveals

Researchers analysing Aging Cell data from over 33,000 US adults found a U-shaped link between daily eating window length and mortality. Eating for 11–12 hours per day was tied to the lowest risk, while very short (<8h) or long (≥15h) windows raised death risk, especially in older and White participants.

15 Sep 2025

High BMI and obesity may not always increase mortality risk

It is possible to be "fat but fit", new research being presented at the annual meeting of the European Association for the Study of Diabetes (EASD) in Vienna, Austria (15-19 September) suggests.

15 Sep 2025

Cannabis use may quadruple the risk of developing diabetes

Cannabis use is linked to an almost quadrupling in the risk of developing diabetes, according to an analysis of real-world data from over 4 million adults, being presented at this year's Annual Meeting of The European Association for the Study of Diabetes (EASD) in Vienna, Austria (15-19 Sept).

15 Sep 2025

Metabolism News and Research

Latest Metabolism News and Research

PRMT5 inhibition induces ferroptosis and enhances immunotherapy efficacy in renal cell carcinoma

New quintuple agonist shows promise for treating obesity and type 2 diabetes

Coffee protects the liver by blocking inflammation and scarring, review finds

Glucose-fructose mix found in sugary drinks fuels colorectal cancer metastasis

Metabolic activity found to control the tempo of embryo segmentation clock

Microplastics pose potential risks to bone health

Evening meals hold the key to morning glucose control in prediabetes

Advancing drug discovery with AI, generative chemistry, and 3D molecular design

Scientists unveil new obesity drug that reprograms fat and energy use

Holder vs Retort: How milk pasteurization shapes preterm infants’ gut health

New genetic test can help predict how people will respond to weight-loss medications

Peroxisomes identified as alternative heat producers in brown fat

High fat diet impairs memory formation through autophagy dysfunction

New AI model predicts surgical complications more accurately than current scores

Researchers provide new insights into how exercise helps lose weight

Cleveland Clinic study shows lasting benefits of weight-loss surgery over GLP-1 medicines

Foods taste sweeter or saltier than before for some people taking Ozempic, Wegovy or Mounjaro

Daily meal timing influences longevity risk in adults, study reveals

High BMI and obesity may not always increase mortality risk

Cannabis use may quadruple the risk of developing diabetes

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