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Body fat percentage outperforms BMI in predicting early mortality

Although body mass index (BMI) is widely used in clinics as the standard measure of body composition, it can potentially misclassify muscular individuals as overweight and miss cases of "normal-weight obesity," masking serious metabolic and heart disease risks.

29 Jul 2025

Gut microbial metabolites restore hormone-producing cells in obesity

New research from scientists at the Marshall University Joan C. Edwards School of Medicine reveals that certain gut microbial byproducts may hold promise as a novel therapy for obesity-associated metabolic complications by restoring critical hormone-producing cells in the intestine.

29 Jul 2025

New RNA therapy reverses symptoms of progeria in mouse models

Children who develop deep wrinkles, stunted growth, and rapidly aging bones and blood vessels as early as 1 to 2 years of age may be suffering from Hutchinson-Gilford Progeria Syndrome (HGPS), a rare and incurable genetic disorder that affects approximately one in eight million people.

29 Jul 2025

NR2F1 drives fibrotic cataract formation through activation of STAT3

Cataracts remain one of the most prevalent and debilitating eye conditions, often requiring surgical intervention to restore sight. Yet even after surgery, many patients develop anterior subcapsular cataracts (ASC), characterized by fibrotic tissue growth beneath the lens capsule.

29 Jul 2025

Pyruvate identified as a promising oral treatment for ulcerative colitis

Ulcerative colitis (UC) is a chronic inflammatory disease marked by intestinal pain, bleeding, and impaired gut barrier function.

29 Jul 2025

New blood markers predict kidney disease and mortality in diabetes

Kidney complications in diabetes often progress silently, putting patients at risk of life-threatening outcomes long before any symptoms appear. Identifying individuals with diabetes who are at risk of rapid kidney function decline or early death has challenged doctors for decades, with traditional markers like serum creatinine and urinary albumin falling short of accurately predicting these risks.

29 Jul 2025

Plant-based agent inhibits key protein to reduce bronchial thickening

A plant-based agent inhibits a protein that, among other things, is responsible for the dreaded thickening of the bronchial wall.

29 Jul 2025

Immunotherapy shows promise in changing leukemia’s cellular environment

Scientists studying a hard-to-treat form of blood cancer called acute myeloid leukemia (AML) have found that a type of treatment - immunotherapy - may help change the environment where cancer cells live, possibly helping the immune system respond more effectively.

29 Jul 2025

Artificial protein sensor offers new way to measure cortisol with a smartphone

Cortisol is a crucial hormone that regulates many important bodily functions like blood pressure and metabolism, and imbalances of this stress hormone can lead to health problems.

29 Jul 2025

Groundbreaking Living Brain Project challenges decades of assumptions in neuroscience

In a revealing Genomic Press Interview published today in Genomic Psychiatry, Dr. Alexander W. Charney describes how treating patients with schizophrenia transformed his scientific pursuits from abstract questions to an urgent mission, ultimately leading to discoveries that challenge fundamental assumptions in neuroscience research.

29 Jul 2025

Exonate plans 'CLEAR-DE' Phase IIb clinical trial of lead candidate EXN407 for diabetic eye disease

Exonate Ltd., a biotechnology company developing novel, non-invasive, small-molecule therapeutics for patients with retinal vascular diseases, today announced plans to initiate a Phase IIb clinical trial for its lead candidate EXN407.

29 Jul 2025

Changing the narrative on hormone-related mood disorders in women

In a wide-ranging Genomic Press Interview published today in Brain Medicine, Dr. David R. Rubinow recounts the serendipitous path that led him to overturn decades of medical assumptions about hormone-related mood disorders in women.

29 Jul 2025

New research provides the first clinically relevant overview of childhood brain tumors

Childhood brain tumor survival depends on the type of tumor. Comparing survival rates across countries is difficult, because brain tumors aren't recorded in the same way everywhere in Europe. A new study led by the Princess Máxima Center is helping to change that. For the first time, the research provides a clear and clinically relevant overview of survival outcomes for children with brain tumors.

29 Jul 2025

What’s better for your gut: lean beef or chicken? Science weighs in

A crossover trial in healthy young adults found that both lean chicken and beef diets reduced gut microbial richness, but only chicken caused significant diversity loss. The study highlights that lean local beef may have a milder impact on the gut microbiome than chicken.

29 Jul 2025

How a leaky gut could be putting your heart at risk

Researchers reviewed recent studies showing that gut dysbiosis contributes to heart failure by weakening the gut barrier, enabling harmful metabolites like TMAO to trigger inflammation and cardiac damage. The review highlights a bidirectional “gut-heart axis” and points to new avenues for dietary and microbial therapies.

28 Jul 2025

Moderate coffee and tea habits linked to sharper thinking in seniors

Moderate coffee intake and both moderate and high tea consumption are associated with a slower decline in fluid intelligence among older adults over nearly a decade. High coffee intake, however, is linked to a faster decline in cognitive function.

28 Jul 2025

Plant compounds show promise against leishmaniasis through mitochondrial targeting

Leishmaniasis, a neglected tropical disease caused by Leishmania parasites, affects millions globally. Current synthetic treatments face limitations including toxicity, cost, and resistance.

28 Jul 2025

New computer program mimics cell behavior for faster medical discoveries

Using mathematical analysis of patterns of human and animal cell behavior, scientists say they have developed a computer program that mimics the behavior of such cells in any part of the body.

28 Jul 2025

Most dairy foods linked to neutral or better health but yogurt stands out for real benefits

A major scoping review of recent systematic reviews and meta-analyses finds that most dairy products are either neutral or modestly protective for heart, cancer, metabolic, and mortality outcomes in adults. Yogurt and other fermented dairy consistently show the strongest health associations, while some risks remain for specific cancers.

28 Jul 2025

Female body odor variations can shape male behavior and emotions

Researchers at the University of Tokyo explored how female body odor can influence behaviors in men. They found certain scent compounds in female body odor increased during ovulation and can subtly influence how men feel.

28 Jul 2025