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Single-cell analysis reveals gene disruptions in early-onset Alzheimer's brain regions

A new study led by researchers at UTHealth Houston investigated both gene expression and regulation at single cell levels to reveal disruptions in gene function in three brain regions of patients with sporadic early onset Alzheimer's disease.

13 Jan 2026

New CHEST guidelines offer evidence-based biologic selection for severe asthma

The American College of Chest Physicians (CHEST) recently released a new clinical guideline on biologic management in severe asthma.

13 Jan 2026

Magnetic torque boosts cardiac organoid maturation, mimicking heart development

Heart disease remains the leading cause of death worldwide, yet progress in understanding and treating cardiac disorders is limited by the shortcomings of existing experimental models.

13 Jan 2026

Short-term, calorie-restrictive diet improves Crohn’s disease symptoms

A Stanford Medicine-led study finds a short-term, calorie-restrictive diet significantly improved symptoms.

13 Jan 2026

Petrolatum ointments cause microshunt swelling, rupture in glaucoma patients

Widely-used eye ointments can cause glaucoma implants to swell and potentially rupture, according to new research from Nagoya University in Japan.

13 Jan 2026

New research identifies faulty TRPM3 ion channel in ME/CFS immune cells

A faulty ion channel function is a consistent biological feature of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), providing long-awaited validation for hundreds of thousands of Australians living with the debilitating illness.

13 Jan 2026

Blocking liver enzyme Caspase-2 may increase long-term cancer risk

Scientists have discovered that blocking a key cellular enzyme thought to protect against fatty liver disease may instead increase the risk of chronic liver damage and cancer as we age.

13 Jan 2026

Scientists discover the brain region behind high blood pressure

Scientists have discovered that a part of the brain may be behind high blood pressure.

13 Jan 2026

New test could improve future diagnosis and monitoring of IBD

A test that rapidly detects signs of inflammatory bowel disease (IBD) in stool samples could improve future diagnosis and monitoring of the condition, a study suggests.

13 Jan 2026

Researchers uncover unexpected role of the cerebellum in schizophrenia's negative symptoms

Apathy, social withdrawal, and loss of motivation — the so-called ''negative'' symptoms of schizophrenia — are among the most disabling and hardest to treat.

13 Jan 2026

Novel drug combination overcomes resistance in aggressive KRAS-mutated lung cancer

A research team at the Medical University of Vienna has discovered a new approach to treating a particularly frequent and difficult-to-treat form of lung cancer.

13 Jan 2026

Research finds persistent prescribing of risky medications to older adults with dementia

Despite years of clinical guidelines warning against the practice, one in four Medicare beneficiaries with dementia is prescribed brain-altering medications linked to falls, confusion, and hospitalization, according to new research to be published January 12 in the peer-reviewed journal JAMA.

12 Jan 2026

Analysis reveals why head and neck cancer clinical trials end early

Head and neck cancer trials are frequently derailed before they can deliver answers. A new analysis suggests that the most common reasons are sponsor decisions related to safety or effectiveness and poor patient recruitment.

12 Jan 2026

Burn pit smoke exposure leaves lasting carbon particles in veterans’ lungs

A new study led by researchers at National Jewish Health provides quantitative evidence linking burn pit smoke exposure during military deployment to increases in harmful carbon-based particles in the lungs of post-9/11 veterans with distal lung disease.

12 Jan 2026

New eye injection restores sight in untreatable hypotony

A new study demonstrates the effectiveness of a widely-used eye injection to manage the previously untreatable rare condition, hypotony, in a project by clinical researchers at University College London (UCL) and Moorfields Eye Hospital.

12 Jan 2026

Digital twin technology guides personalized treatment for brain cancer patients

A new machine-learning-based approach to mapping real-time tumor metabolism in brain cancer patients, developed at the University of Michigan, could help doctors discover which treatment strategies are most likely to be effective against individual cases of glioma.

12 Jan 2026

Resistance to rezatapopt: New TP53 mutations identified in cancer patients

Mutations in the tumor suppressor TP53 are a common cause of cancer, making the altered protein an attractive target for therapeutics.

12 Jan 2026

Blood test opens the doors to early diagnosis and prevention of Crohn's disease

Sinai Health researchers have shown a blood test that can predict Crohn's disease years before symptoms appear, opening the doors to early diagnosis and potentially prevention.

12 Jan 2026

New technology enables cuffless non-invasive blood pressure monitoring

A new technology has been developed that enables cuffless non-invasive blood pressure monitoring by using ultrasonic to track real-time changes in vascular diameter-without the need for a traditional cuff.

12 Jan 2026

Researchers identify possible target for new therapies against periodontitis aggravated by smoking

Smoking tobacco is known to worsen symptoms of periodontitis and reduce responsiveness to treatment. Using high-resolution spatial transcriptomics, researchers identified differences between smokers and non-smokers in the expression of genes that weaken gum epithelial integrity and cause bone damage through inflammation.

12 Jan 2026