Biochemistry

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Sneaking large drug-carrying biological molecules into cells using a novel drug delivery system

Scientists from Nanyang Technological University, Singapore have developed a novel method of delivering drugs into human cells using large biological molecules, by first encasing them in a protein-based microdroplet.

16 Mar 2022

Previously unknown bacterial enzyme makes new type of polysaccharide

Strings of sugars called polysaccharides are the most abundant biopolymers on Earth. Because of their versatile and environmentally friendly properties, these molecules could eventually replace some plastics.

16 Mar 2022

Researchers illuminate the link between autophagy and the body's metabolic response to fasting

The coming of spring harkens spring cleaning; a time to de-clutter your home and discard things that are no longer needed. In the body, a cellular process called autophagy occurs regularly to "de-clutter" our cells.

15 Mar 2022

Modifying red blood cells to create a promising new vehicle for vaccine delivery

Physicists, chemists and immunologists at McMaster University have teamed up to modify red blood cells to transport viral agents which can safely trigger the immune system to protect the body against SARS-CoV-2, creating a promising new vehicle for vaccine delivery.

11 Mar 2022

New analysis method to identify interacting proteins in a protein degrader-dependent manner

Protein degraders, which induce the protein degradation of target proteins, are expected to be the "next-generation drugs" because they can remove disease-related proteins from cells.

8 Mar 2022

UH researchers receive grant for developing new imaging technique to peer into ribosomes

Two University of Houston researchers are developing a type of spectroscopy to help understand how ribosomes make proteins deep within cells, the discovery of which could potentially guide drug design to treat cancers and viral infections.

8 Mar 2022

A promising approach for COVID-19 prophylaxis

SARS-CoV-2 viruses can hide from recognition by the immune system. However, the antiviral immune receptor RIG-I can be stimulated, which improves protection against lethal SARS-CoV-2 infections.

8 Mar 2022

GlyNAC supplementation can increase lifespan and improve multiple age-associated defects

Many people aspire to live longer, healthier lives. A researcher at Baylor College of Medicine, Dr. Rajagopal Sekhar, associate professor of medicine in the section of endocrinology, diabetes and metabolism, has been studying aging for the past 20 years to better understand its biological underpinnings and develop nutritional strategies to promote healthy aging.

7 Mar 2022

Manipulating carotenoids can improve plant growth, stress tolerance and increase yield

Manipulating the content of carotenoids, such as ß-carotene, has been found to improve plant growth and increase yield and tolerance to abiotic stresses such as drought and salinity.

7 Mar 2022

CABI scientists reveal the safety of a classical biological control agent against Drosophila suzukii

CABI scientists have led new research which highlights the safety of a classical biological control agent against the devastating invasive fruit fly Drosophila suzukii which attacks over 150 wild and cultivated fruits, including cherries, blueberries and strawberries, as well as the fruits of ornamental plants.

7 Mar 2022

Study may pave the way for better multiple sclerosis drugs

Investigators from Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center have discovered how a drug for multiple sclerosis interacts with its targets, a finding that may pave the way for better treatments.

4 Mar 2022

A new method to produce complex natural products in amoebae

A research team at the Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute in Jena, Germany has developed a new method to produce complex natural products in amoebae.

4 Mar 2022

Researchers design a peptide hydrogel for cell spheroids production

This study is led by Prof. Zhimou Yang and Prof. Quan Chen (College of Life Sciences in Nankai University), and Prof. Jianfeng Liu (Institute of Radiation Medicine, Chinese Academy of Medical Sciences). Prof. Zhimou Yang, who is working in the research field of peptide self-assembly biomaterials for more than 15 years, designed the peptide hydrogel for cell spheroids production.

4 Mar 2022

High-fat diet combined with liquid fructose intake accelerates fat accumulation in the liver

A high-fat diet is not enough to cause short-term fatty liver disease. However, if this diet is combined with the intake of beverages sweetened with liquid fructose, the accumulation of fats in the liver accelerates and hypertriglyceridemia —a cardiovascular risk factor— can appear.

4 Mar 2022

Texas A&M team continues research on the potential cure for Menkes disease

A life-saving cure solution for Menkes Disease, a copper deficiency in young children, is at the center of a licensing agreement by the The Texas A&M University System, through the Intellectual Property and Commercialization office of Texas A&M AgriLife Research, and a California-based biopharmaceutical company, Engrail Therapeutics.

3 Mar 2022

Lipidomic profiling may provide early prediction of type 2 diabetes and cardiovascular disease risk

Simultaneous measurement of dozens of types of fats in the blood ("lipidomics") can predict the risk of developing type 2 diabetes (T2D) and cardiovascular disease (CVD) years in the future, according to a new study publishing March 3rd in the open-access journal PLOS Biology from Chris Lauber of Lipotype, Germany, and colleagues.

3 Mar 2022

Research uncovers a new molecular interaction mechanism for SARS-CoV2

The virus causing the current COVID-19 pandemic is the SARS-CoV-2. Soon after the pandemic outbreak in 2019, the ACE-2 protein, which is present on some of our cells´ surface, was identified as the receptor facilitating host cell viral entry.

3 Mar 2022

Sugar-decorated proteins in mucus could prevent SARS-CoV-2 viruses from spreading from surfaces

Early in the pandemic, many people fastidiously disinfected surfaces because laboratory studies predicted that SARS-CoV-2 could be easily transmitted in this way.

2 Mar 2022

Australian bull ants' venom component exploits a pain pathway in mammals

Australian bull ants have evolved a venom molecule perfectly tuned to target one of their predators – the echidna – that also could have implications for people with long-term pain, University of Queensland researchers say.

2 Mar 2022

New type of drug delivery vehicle mimics the properties of a red blood cell

From the liver to the kidneys to the lungs, the human body is equipped with many levels of filters, which protect the body from harmful outside materials. But this system also has its downsides. Critically important drugs such as chemotherapy or multiple sclerosis treatments are also foreign materials, so the body filters out a large portion of these drugs – up to 90%, in some cases.

2 Mar 2022

Biochemistry

Sneaking large drug-carrying biological molecules into cells using a novel drug delivery system

Previously unknown bacterial enzyme makes new type of polysaccharide

Researchers illuminate the link between autophagy and the body's metabolic response to fasting

Modifying red blood cells to create a promising new vehicle for vaccine delivery

New analysis method to identify interacting proteins in a protein degrader-dependent manner

UH researchers receive grant for developing new imaging technique to peer into ribosomes

A promising approach for COVID-19 prophylaxis

GlyNAC supplementation can increase lifespan and improve multiple age-associated defects

Manipulating carotenoids can improve plant growth, stress tolerance and increase yield

CABI scientists reveal the safety of a classical biological control agent against Drosophila suzukii

Study may pave the way for better multiple sclerosis drugs

A new method to produce complex natural products in amoebae

Researchers design a peptide hydrogel for cell spheroids production

High-fat diet combined with liquid fructose intake accelerates fat accumulation in the liver

Texas A&M team continues research on the potential cure for Menkes disease

Lipidomic profiling may provide early prediction of type 2 diabetes and cardiovascular disease risk

Research uncovers a new molecular interaction mechanism for SARS-CoV2

Sugar-decorated proteins in mucus could prevent SARS-CoV-2 viruses from spreading from surfaces

Australian bull ants' venom component exploits a pain pathway in mammals

New type of drug delivery vehicle mimics the properties of a red blood cell

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

How GLP‑1 Agonists Are Shaping the Future of Obesity Treatment With Dr Bryony Henderson

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production

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